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207402 Setomimycin CAS: 69431-87-4

Specifications
References
CAS Number
69431-87-4
Grade
Purified
Molecular Formula
C₃₄H₂₈O₉
Molecular Weight
580.6
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
Setomimicin, AM-2947, Antibiotic A 39183B, BRN 5202658, 1,​1’-​Diacetyl-​2,​3-​dihydro-​2,​5,​5’,​10,​10’-​pentahydroxy-​2,​2’-​dimethyl-[9,​9’-​bianthracene]​-​4,​4’(1H,​1’H)​-​dione

Setomimycin is a pre-anthraquinone originally isolated from S. pseudovenezuelae. It is active against a variety of Gram-positive bacteria, including S. aureus, B. subtilis, B. cereus, and M. smegmatis (MICs = 1.56-3.13ug/ml).1 It also reduces tumor growth in a Sarcoma-180 mouse solid tumor model when administered at a dose of 200 mg/kg per day for seven days.

Synonyms
Setomimicin; AM-2947; Antibiotic A 39183B; BRN 5202658, 1,​1’-​Diacetyl-​2,​3-​dihydro-​2,​5,​5’,​10,​10’-​pentahydroxy-​2,​2’-​dimethyl-[9,​9’-​bianthracene]​-​4,​4’(1H,​1’H)​-​dione
CAS No
69431-87-4
Source
Streptomyces aurantiacus JA 4570
Molecular Formula
C₃₄H₂₈O₉
Molecular Weight
580.6
Solubility
Chloroform and DMSO
Purity
≥90%
Appearance
Supplied as a solid
Storage and Stability
May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 1 year after receipt. Protect from light when in solution. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. A new antibiotic, setomimycin, produced by a strain of Streptomyces: S. Omura, et al.; J. Antibiotics 31: 1091 (1978) 2. Structure and biosynthesis of setomimycin, a novel 9,9`-bianthryl antibiotic: K. Kakinuma, et al.; JACS 102: 7493 (1980). 3. Bioactive Secondary Metabolites from Marine and Terrestrial Bacteria: Isoquinolinequinones, Bacterial Com- pounds with a Novel Pharmacophor: M. Shabaan; Dissertation Univ. Göttingen (2004) (Setomimycin isolation, Spectral data)
USBio References
No references available
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