Tripolin A CAS 1148118-92-6

CAS Number

1148118-92-6

Grade

Highly Purified

Molecular Formula

C15H11NO3

Molecular Weight

253.3

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Specific non-ATP competitive Aurora A kinase inhibitor. Does not significantly inhibit Aurora B kinase in mammalian cells. Reduces localization of pAurora A on spindle microtubules (MTs), affects centrosome integrity, spindle formation and length and MT dynamics in interphase.

Sequence

[(3E)-3-[(2,5-Dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one]

Solubility

DMSO (10mg/ml)

Molecular Weight

~253.3

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Purity

≥98% (HPLC, NMR)

Form

Supplied as a yellow solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules: I.A. Kesisova, et al.; PLoS One 8: e58485 (2013)