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207458 Z-VRPR-FMK (Z-Val-Arg-Pro-DL-Arg-FMK . TFA) CAS: 1381885-28-4 (free base)

Specifications
References
CAS Number
1381885-28-4 (free base)
Grade
Purified
Molecular Formula
~676.8+114.0
Molecular Weight
3149106.232
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei.

Source
Synthetic
Sequence
Z-Val-Arg-Pro-DL-Arg-FMK . TFA
Appearance
Supplied as a white to slightly yellow solid.
Purity
≥90% (HPLC)
Identity
Determined by MS.
Solubility
H2O
Molecular Weight
~676.8+114.0
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Source
Synthetic
Purity
~90% (HPLC)
Concentration
Not determined
Form
Supplied as a white to slightly yellow solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9: 272 (2008). 2. Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma: S. Hailfinger, et al.; PNAS 106: 19947 (2009). 3. Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2: S.I. Gringhuis, et al.; PLoS Pathogens 7: e1001259 (2011). 4. Crystal structure of a Trypanosoma brucei metacaspase: K. McLuskey, et al.; PNAS 109, 7469 (2012) 5. MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo: L. Fontan, et al.; Cancer Cell 22: 812 (2012). 6. The protease activity of the paracaspase MALT1 is controlled by monoubiquitination: C. Pelzer, et al.; J. Immunol. 14: 337 (2012)
USBio References
No references available
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