Technical Data

215890
CAS Number
717907-75-0
Grade
Highly Purified
Molecular Formula
C21H20F3N7O3S
Molecular Weight
507.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
PF-562271

Potent ATP-competitive reversible inhibitor of FAK and Pyk2. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nm, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nm. PF-562,271 was evaluated against multiple kinases and displays >100X selectivity against a long list of non target kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/ml using injections.

Synonyms
PF562271, N-[3-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-methanesulfonamide Hydrochloride
CAS Number
717907-75-0
Molecular Weight
507.5
Molecular Formula
C21H20F3N7O3S
Target
FGFR
Kinase Group
RTK
Substrate
Tyrosine
Appearance
Supplied as a solid.
Purity
≥95%
Solubility
DMSO or ethanol
Storage and Stability
Store short term at 4°C. Stable for 12 months after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271: W.G. Roberts, et al.; Cancer Res. 68, 1935 (2008). 2. Selectivity data: assessment, predictions, concordance, and implications. C. Gao, et al.; J. Med. Chem. 56, 6991 (2013).
USBio References
No references available
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