215892
CAS Number
1292300-75-4Grade
Highly PurifiedMolecular Formula
C13H17N5O3SMolecular Weight
323.4EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
4°CTASP-0415914
Potent, orally applicable PI3K y inhibitor. PI3Ky is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP-0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine in vivo models. PI3Ky IC(50) 29nm, AKT IC(50) 294nm.
Molecular Formula
C13H17N5O3S
Form
Supplied as a solid.
Storage and Stability
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase y inhibitor for the treatment of inflammatory diseases: Y. Oka, et al.; Bioorg. Med. Chem. 21, 7578 (2013)USBio References
No references available