TASP-0415914 CAS 1292300-75-4

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215892 TASP-0415914 CAS: 1292300-75-4

Specifications

References

CAS Number

1292300-75-4

Grade

Highly Purified

Molecular Formula

C13H17N5O3S

Molecular Weight

323.4

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

4°C

Potent, orally applicable PI3K y inhibitor. PI3Ky is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP-0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine in vivo models. PI3Ky IC(50) 29nm, AKT IC(50) 294nm.

CAS Number

1292300-75-4

Molecular Weight

323.4

Molecular Formula

C13H17N5O3S

Target

PI3Kγ

Form

Supplied as a solid.

Purity

≥95%

Solubility

DSMO

Storage and Stability

Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

1. Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase y inhibitor for the treatment of inflammatory diseases: Y. Oka, et al.; Bioorg. Med. Chem. 21, 7578 (2013)