3-Nitropropionic Acid CAS 504-88-1

CAS Number

504-88-1

Grade

Highly Purified

MDL Number

MFCD00007406

Molecular Formula

C₃H₅NO₄

Molecular Weight

119.1

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

4°C

3-NP, 3-NPA, 3NPA

A cell-permeable, irreversible inactivator (~3mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.

Synonyms

3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA

CAS Number

504-88-1

Molecular Formula

C₃H₅NO₄

Solubility

DMSO or EtOH

Molecular Weight

119.1

Storage and Stability

Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

Beal, M., et al. 1993, J. Neurosci. 13, 4181.|Pang, Z., et al. 1997, J. Neuroscience 17, 3064.|Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.|Garcia, M., et al. 2002, J. Neurosci. 22, 2174.|Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.