Bicuculline CAS 485-49-4

CAS Number

485-49-4

Grade

Highly Purified

MDL Number

MFCD00005006

Molecular Formula

C₂₀H₁₇NO₆

Molecular Weight

367.35

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

(6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one; (+)-Bicuculline; d-Bicuculline; NSC 32192

A potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.

CAS No

485-49-4

Molecular Formula

C₂₀H₁₇NO₆

Molecular Weight

367.35

Appearance

Pale yellow solid

Purity

≥99% (HPLC)

Melting Point

193-197°C (lit)

Primary Target

GABA-A

Primary Target IC50

740Nm

Solubility

DMSO

Elemental Analysis

C: 64-66%; H: 4-5.5%; N: 3-5%

Water by CHN (mol)

≤1.0mol

Optical Rotation

+130º-145º

Storage and Stability

Powder is stable for 6 months after receipt at 4°C. Hygroscopic. Under inert atmosphere.

References

Curtis, et al., Nature, 226, 1222 (1970); Avoli, M., et al., J. Physiol. Pharmacol., 75, 526 (1997); Chebib, M., et al., Clin. Exp. Pharmacol. Physiol., 26, 927 (1999)