A positive allosteric modulator selective for NR2C/D containingnMDA receptors (EC50 = 2.7 and 2.8uM for NR2C and NR2D, respectively). Increases channel opening frequency of recombinant NR2C/D containingnMDA receptors by two-fold without altering mean open time or EC50 values for glutamate or glycine bindings. No effect on NR2A or NR2B subtypes.
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