A potent, nonselective, and noncompetitive antagonist of nAChRs (IC50 = 640nM, 2.5uM, 3.6uM and 6.9uM for alpha3beta4, alpha4beta2, alpha3beta2 and alpha7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette's syndrome, Schizophrenia and various cognitive and mood disorders).
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