217569
CAS Number
1186195-60-7Grade
Highly PurifiedMolecular Formula
C11H8N2SHClEU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
4°CMTEP Hydrochloride (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Hydrochloride)
A non-competitive, potent antagonist highly selective for mGlu5 receptors (IC50 = 5nM). Biologically active admitted orally or systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
Primary Target
mGlu5 receptors
Storage and Stability
May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Concentration
Not determined
Form
Supplied as a cream solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Cosford, N., et al. 2003. J. Med. Chem. 46, 204.|Varty, B., et al. 2005. Psychopharmacol. 179, 207.|Domin, H., et al. 2006. Pharmacol. Reports. 58, 846.|Johnston, Tom H., et al. 2010. J. Pharmacol. & Exp. Therapeutics 333, 865.|McIldowie, M., et al. 2010. J. Pharm. Sci. 99, 234.|Timmer, M., et al. 2012. Psychopharmacol. 221, 91.|Wang, X., et al. 2013. Addict. Biol. 18, 40.USBio References
No references available