Technical Data

217655
Grade
Highly Purified
Molecular Weight
2629.1
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C
PI 3-K Inhibitor XVIII (p110 beta-G beta gamma Interaction Inhibitor peptide, Cell-permeable, Myr-N-KAAEIASSDSANVSSRGGKKFLPV-NH2)

An N-myristoylated cell-permeable PI 3-K p110 beta-derived G beta-gamma-binding peptide (aa514-537 in p110 beta C2-helical linker region) that prevents G beta-gamma-, but not RTK-, mediated p100 beta activation both in cell-free assays (1uM) and in cultures (30uM in p110 beta/p85/Akt/G beta-gamma-transfected HEK 293E cells) without affecting basal p100 beta activity, p110 beta-Rab5 interaction, nor G beta-gamma-dependent activation of adenylyl cyclase or p101-p110-gamma dimer. The ATP-competitive p110 beta inhibitior TGX-221 can be used in conjunction for studying G beta-gamma dependency of p110 beta-mediated cellular functions.

Sequence
N-Myr-Lys-Ala-Ala-Glu-Ile-Ala-Ser-Ser-Asp-Ser-Ala-Asn-Val-Ser-Ser-Arg-Gly-Gly-Lys-Lys-Phe-Leu-Pro-Val-NH2
Solubility
H2O
Primary Target
Gbeta-gamma subunit of G-proteins
Molar Mass
2629.1
Storage and Stability
May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~95% (HPLC)
Concentration
Not determined
Form
Supplied as a white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
No references available
USBio References
No references available
United States Biological | 4 Technology Way | Salem, MA 01970
Phone 800-520-3011 | Fax 978-594-8052 | Website www.usbio.net