PKC Activator VII, CGK062 (Protein Kinase C Activator VII)
A cell permeable coumarin-containing compound that is shown to activate PKCalpha activity and induce cellular PKCalpha membrane translocation (Effective conc. 12.5 to 50uM) as well as PKCalpha-mediated signaling events. Effectively affects the viability of CRT-dependent cancer cells (IC50 = 1.62 to 18.6uM; 48h) in vitro and suppresses PC3-derived tumor expansion in mice (50 & 100mg/kg/day; i.p) in vivo, while exhibiting little cytotoxicity toward WI38 normal fibroblasts.
Molecular Formula
C₂₃H₂₀O₇
Primary Target IC50
12.2uM
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Form
Supplied as an off-white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
