A cell-permeable steroidal compound that acts as a highly selective SHIP1 activity inhibitor (IC50=10uM) over SHIP2 and PTEN (IC50>1mM in a phosphate release assay). Shown to boost the number of myeloid immunoregulatory cells and circulating granulocytes, and facilitate blood cell recovery in myelosuppressed hosts (60uM, i.p. in mice). Also, promotes apoptosis and reduces SHIP1-expressing KG1 and C1498 cell growth. SHIP2 Inhibitor, AS1938909 is also available.
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