217808
CAS Number
104104-50-9Grade
Highly PurifiedMolecular Formula
C15H17N3O3•HBrMolecular Weight
368.23EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
4°CSR95531 (Gabazine) Hydrobromide
Gabazine; GABAA Receptor Antagonist; SR-95531; 6-imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid, monohydrobromide
A selective, competitive antagonist of GABAA receptor (IC50 = 440nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100uM). Also shown to block glycine receptors, but with low affinity (Kb = 190uM).
Synonyms
Gabazine; GABAA Receptor Antagonist; SR-95531; 6-imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid, monohydrobromide
Molecular Formula
C15H17N3O3 • HBr
Primary Target IC50
440nM
Proton NMR
Conforms to structure
Elemental Analysis
C% :47.50-50.50% H%: 4.00-6.00% N%: 10.00-13.00%
Solubility
Water (25mM); MeOH:PBS (pH 7.2); (1:1): 0.5mg/ml; Methanol: 1mg/ml
Storage and Stability
Lyophilized powder may be stored at 4°C Do not freeze. Stable for 6 months after receipt at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Muroi, Y., et al. 2009. Biophys. J. 96, 499. 2. Beato, M., et al. 2007. J. Physiol. 580, 171. 3. Uchida, I., et al. 1996. Eur. J. Pharmacol. 307, 89.USBio References
No references available