L-3-(p-Aminophenyl)alanine; 4-Amino-L-phenylalanine; Aminophenylalanine; L-Phe(4-NH2)-OH·HCl; p-Amino-L-phenylalanine hydrochloride H-Phe(4-NH2)-OH·HCl
p-Amino-L-phenylalanine hydrochloride (PABA) is a type of amino acid that is used in the synthesis of melphalan hydrochloride, a drug used to treat cancer. PABA is a white crystalline powder that can be dissolved in water and formic acid. It has been shown to interact with the hydrophilic interaction chromatography column and flow rate sensor in order to improve the chromatographic separation of ammonium formate. PABA has also been found to be chiral and can be converted into its enantiomeric form by means of an organic solvent, such as acetonitrile. The impurities of PABA are mandelic acid and l-phenylalanine. These impurities are separated from PABA by means of HPLC analysis.
Synonyms
L-3-(p-Aminophenyl)alanine; 4-Amino-L-phenylalanine; Aminophenylalanine; L-Phe(4-NH2)-OH·HCl; p-Amino-L-phenylalanine hydrochloride H-Phe(4-NH2)-OH·HCl
Molecular Formula
C9H12N2O2·HCl
Appearance
White to off-white powder
Solubility (0.1g in 2 ml H2O)
Clear solution
Method of Determining Identity
1H NMR and Mass Spectometry
Infared Spectrum
Conforns to structure
Optical Rotation
As reported
Melting Point
As reported
Loss on Drying
As reported
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
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