4-Iodo-L-Phenylalanine (H-Phe(4-I)-OH)
H-Phe(4-I)-OH; S)-2-Amino-3-(4-iodophenyl)propanoic acid
4-Iodo-L-phenylalanine is an unlabeled amino acid that has been shown to inhibit the protein synthesis of cancer cells. It binds to the thrombin receptor and inhibits the activation of proteases, thereby inhibiting cancer cell growth. 4-Iodo-L-phenylalanine also inhibits translation by binding to the ribosome during the translation process and binding to the hydroxyl group on a mRNA molecule during transcription. This inhibition leads to a decrease in protein synthesis and cell proliferation.
Synonyms
H-Phe(4-I)-OH; S)-2-Amino-3-(4-iodophenyl)propanoic acid
Molecular Formula
C9H10INO2
Purity
≥98% (HPLC, Chiral)
Melting Point
~240°C (lit)
Optical Rotation
[a]D20 = -6.5 ± 2º (C=2 in 80% AcOH)
Solubility
Partly miscible with water.
Method of Determining Identity
Proton NMR and Mass Spectroscopic and Mass Spectrometric Analysis
Loss on Drying
As Reported
Infared Spectrum
Conforms
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.