Merrifield Resin, 100-200 mesh (Chloromethylated Polystyrene)
Chloromethylated polystyrene; Chloromethylated stryene/divinylbenzene copolymer; Chloromethylated styrene-divinylbenzene resin; Copolymer of styrene and divinylbenzene; chloromethylated; Poly(styrene-co-vinylbenzyl chloride-co-divinylbenzene); Polystyrene crosslinked with divinylbenzene chloromethylated
Chloromethyl polystyrene and styrene monomers are copolymerized in order to obtain the Merrifield resin. This method avoids the use of carcinogenic chloromethyl methyl ether. This resin is used in the synthesis of peptide acids using Boc strategy and can be cleaved using HF or TFMSA.
Synonyms
Chloromethylated polystyrene; Chloromethylated stryene/divinylbenzene copolymer; Chloromethylated styrene-divinylbenzene resin; Copolymer of styrene and divinylbenzene; chloromethylated; Poly(styrene-co-vinylbenzyl chloride-co-divinylbenzene); Polystyrene crosslinked with divinylbenzene chloromethylated
Appearance
Pale to yellow to white polymer beads
Infrared Spectrum
Conforms to reference
Substitution
0.8-1.5 meq/g
Loss on Drying (105±3°C, 1.5h)
≤1%
Storage and Stability
Store at RT.
