Chloromethyl polystyrene and styrene monomers are copolymerized in order to obtain the Merrifield resin. This method avoids the use of carcinogenic chloromethyl methyl ether. This resin is used in the synthesis of peptide acids using Boc strategy and can be cleaved using HF or TFMSA.
Synonyms
Chloromethylated polystyrene; Chloromethylated stryene/divinylbenzene copolymer; Chloromethylated styrene-divinylbenzene resin; Copolymer of styrene and divinylbenzene; chloromethylated; Poly(styrene-co-vinylbenzyl chloride-co-divinylbenzene); Polystyrene crosslinked with divinylbenzene chloromethylated
Appearance
Pale to yellow to white polymer beads
Infrared Spectrum
Conforms to reference
Substitution
0.8-1.4meq/g
Loss on Drying (105±3°C, 1.5h)
≤1%
Storage and Stability
Store at RT. Stable for 6 months after receipt.
Certificate of Origin
USA
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
TDS
NCBI
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