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242554 Tyloxapol, USP CAS: 25301-02-4

Specifications
References
CAS Number
25301-02-4
Grade
USP
MDL Number
MFCD00149002
Molecular Formula
(C17H30O4)n
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
p-(1,1,3,3-Tetramethylbutyl)Phenol Polymer with Ethylene Oxide and Formaldehyde; Ethylene Oxide Polymer with Formaldehyde and p-(1,1,3,3-Tetramethylbutyl)phenol; Oxirane Polymer with Formaldehyde and 4-(1,1,3,3-tetramethylbutyl)phenol; Ethylene oxide-formaldehyde-4-(1,1,3,3-tetramethylbutyl)phenol copolymer; Ethylene oxide-formaldehyde-p-octylphenol Copolymer; NSC 90255; Superinone; Triton A 20; Triton WR 1339; Tyloxapol; p-Isooctylpolyoxyethylenephenol Formaldehyde Polymer

Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent[citation needed] (containing mucus and pus) bronchopulmonary secretions administered by inhalation through a nebulizer or with a stream of oxygen. With intraperitoneal injection, tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. This mechanism is used to induce experimental hyperlipidemia in animals. Tyloxapol is the main active ingredient of the medical device Tacholiquin®. Tacholiquin® is an expectorant designated for inhalation and instillation reaching the upper and lower airways.

Synonyms
p-(1,1,3,3-Tetramethylbutyl)Phenol Polymer with Ethylene Oxide and Formaldehyde; Ethylene Oxide Polymer with Formaldehyde and p-(1,1,3,3-Tetramethylbutyl)phenol; Oxirane Polymer with Formaldehyde and 4-(1,1,3,3-tetramethylbutyl)phenol; Ethylene oxide-formaldehyde-4-(1,1,3,3-tetramethylbutyl)phenol copolymer; Ethylene oxide-formaldehyde-p-octylphenol Copolymer; NSC 90255; Superinone; Triton A 20; Triton WR 1339; Tyloxapol; p-Isooctylpolyoxyethylenephenol Formaldehyde Polymer
CAS No
25301-02-4
Molecular Formula
(C17H30O4)n
Appearance
Viscous amber liquid, may exhibit slight turbidity
Identity (UV)
Conforms to structure. Exhibits maximum and minimum at the same wavelengths as RS
Identity (IR)
Conforms to structure
Cloud Point
92-97°C
Free Phenol
No cloudiness or precipitation immediately
Limit of Formaldehyde
≤0.0075%
Ethylene Oxide
≤0.001%
Limit of Anionic Detergents
≤0.075% as sodium lauryl sulfate
Absence of cationic detergents
No blue color in the organic solvent layer
Water (Karl Fisher)
≤1%
pH
5-7
Residue On Ignition
≤1%
Refractive Index (n25D)
1.495 - 1.501
Solubility
Slowly but freely miscible with water. Soluble in glacial Acetic acid, Toluene, and Chloroform.
Storage and Stability
Store at 4ºC. Stable for 6 months after receipt.
References
1. Sehgal, S. S.; Ewing, C. K.; Richards, T.; Taeusch, H. W. (1994). "Modified bovine surfactant (Survanta) versus a protein-free surfactant (Exosurf) in the treatment of respiratory distress syndrome in preterm infants: A pilot study". Journal of the National Medical Association 86 (1): 46–52. PMC 2607653. PMID 8151722. 2. Rubin, B. K.; Ramirez, O.; King, M. (1992). "Mucus rheology and transport in neonatal respiratory distress syndrome and the effect of surfactant therapy". Chest 101 (4): 1080–1085. doi:10.1378/chest.101.4.1080. PMID 1555424. 3. Drugs.com: Tyloxapol definition. 4. Kourounakis, A. P.; Victoratos, P.; Peroulis, N.; Stefanou, N.; Yiangou, M.; Hadjipetrou, L.; Kourounakis, P. N. (2002). "Experimental hyperlipidemia and the effect of NSAIDs". Experimental and molecular pathology 73 (2): 135–138. doi:10.1006/exmp.2002.2449. PMID 12231215.
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