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254331 1-EBIO CAS: 10045-45-1

Specifications
References
CAS Number
10045-45-1
Grade
Highly Purified
Molecular Formula
C9H10N2O
Molecular Weight
162.19
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C

Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.

Synonym
1-Ethyl-2-benzimidazolinone
CAS Number
10045-45-1
Molecular Weight
162.19
Molecular Formula
C9H10N2O
Solubility
DMSO and ethanol to 100mM. Tris buffer solution to 33mM with gentle warming.
Appearance
Supplied as a white solid.
Method for Determining Identity
Proton NMR and Mass Spectrometric Analysis
Purity
≥99%
Storage and Stability
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Devor et al (1996) Modulation of Cl secretion by benzimidazolones. I. Direct activation of a Ca - dependent K channel. Am.J.Physiol.|271 L775. PMID: 8944721.|Ayotunde and Adeagbo (1999) 1-Ethyl-2-benzimidazolinone stimulates endothelial K channels and nitric oxide formation in rat|mesenteric vessels. Eur.J.Pharmacol. 379 151. PMID: 10497901.|Kusama et al (2005) Reduced hyperpolarisation in endothelial cells of rabbit aortic value following chronic nitroglycerine administration.|Br.J.Pharmacol. 146 487. PMID: 16056232.|Kleger et al (2010) Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment|of pacemaker-like cells. Circulation. 122 1823. PMID: 20956206.
USBio References
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