CAS 53552-05-9

CAS Number

53552-05-9

Grade

Highly Purified

Molecular Formula

C₂₁H₂₀ClNO₆

Molecular Weight

417.85

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride

Water-soluble GABAA antagonist. Methochloride salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Synonym

[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride

CAS Number

53552-05-9

Molecular Formula

C₂₁H₂₀ClNO₆

Molecular Weight

417.85

Appearance

Off white solid

Purity

≥99% (HPLC)

TLC [(Pyridine:Acetic acid:Water:Butanol [3:8:11:33])] Rf = 0.46

HPLC

>99.9%

1H NMR

Consistent with structure

Mass Spectrum

Consistent with structure

Microanalysis

Carbon Hydrogen Nitrogen Theoretical 56.7 5.21 3.15

Solubility

Water to 100mM PBS to 100mM

Storage

References

1. Kemp et al (1986) Quantitative evaluation of the potencies of GABA-receptor agonists and antagonists using the rat hippocampal slice preparation. Br.J.Pharmacol. 87 677 PMID: 3011168|2. Seutin et al (1997) Evidence for a non-GABAergic action of quaternary salts of bicuculline on dopaminergic neurones. Neuropharmacology 36 1653 PMID: 9517436|3. Seutin and Johnson (1999) Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 20 268 PMID: 10390643|4. Hill, R. et al.: Brit. J. Pharm., 56, 9 (1976)|5. Yoon, J. et al.: Int. J. Neuro., 120, 752 (2010)

USBio References

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254756 (-)-Bicuculline Methochloride CAS: 53552-05-9

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride

References

USBio References

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