Technical Data

255749
CAS Number
73341-72-7
Grade
Highly Purified
Molecular Formula
C₃₀H₄₂N₂O₈
Molecular Weight
558.66
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Macbecin I
(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin; 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.; (+)-Macbecin I; Macbecin; Macbecin I; NSC 330499

Macbecin I is an ansamycin antibiotic inhibitor of Hsp90 activity.

Synonyms
(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin; 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.; (+)-Macbecin I; Macbecin; Macbecin I; NSC 330499
CAS Number
73341-72-7
Molecular Formula
C₃₀H₄₂N₂O₈
Molecular Weight
558.66
Solubility
DMSO
Purity
≥95%
Appearance
Lyophilized solid
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Martin et al (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. J.Med.Chem. 51 2853. PMID: 18357975.|2. Uehara et al (2003) Natural product origins of Hsp90 inhibitors. Curr.Cancer Drug Targets 3 325. PMID: 14529384.|3. Ono et al (1982) Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I. Gann. 73 938. PMID: 6186564.
USBio References
No references available
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