Macbecin I CAS 73341-72-7

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255749 Macbecin I CAS: 73341-72-7

Specifications

References

CAS Number

73341-72-7

Grade

Highly Purified

Molecular Formula

C₃₀H₄₂N₂O₈

Molecular Weight

558.66

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin; 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.; (+)-Macbecin I; Macbecin; Macbecin I; NSC 330499

Macbecin I is an ansamycin antibiotic inhibitor of Hsp90 activity.

Synonyms

(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin; 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.; (+)-Macbecin I; Macbecin; Macbecin I; NSC 330499

CAS Number

73341-72-7

Molecular Formula

C₃₀H₄₂N₂O₈

Molecular Weight

558.66

Solubility

DMSO

Purity

≥95%

Appearance

Lyophilized solid

Storage and Stability

Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

1. Martin et al (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. J.Med.Chem. 51 2853. PMID: 18357975.|2. Uehara et al (2003) Natural product origins of Hsp90 inhibitors. Curr.Cancer Drug Targets 3 325. PMID: 14529384.|3. Ono et al (1982) Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I. Gann. 73 938. PMID: 6186564.