256448
CAS Number
876310-60-0Grade
Highly PurifiedMolecular Formula
C₂₆H₃₈N₆O₃Molecular Weight
482.62EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°CRF9 (1-Adamantanecarbonyl-Arg-Phe-NH2)
1-Adamantanecarbonyl-Arg-Phe-NH2
Selective NPFF receptor antagonist (Ki values are 58 and 75nM at hNPFF1 and hNPFF2 receptors respectively). Displays selectivity over several related receptors including NPY Y1 GPR10, GPR54, GPR103 and the opioid receptors. Blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo.
Synonyms
1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt
Molecular Formula
C₂₆H₃₈N₆O₃
Molecular Weight
482.62 free base
Appearance
White to off-white solid
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Wang et al (2008) Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice. Peptides 29 1183 PMID: 18406009|Simonin et al (2006) RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc.Natl.Acad.Sci.USA 103 466|Fang et al (2008) Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist. Regul.Peptides 147 45USBio References
No references available