TTNPB

256979

CAS Number

71441-28-6

Grade

Purified

Molecular Formula

C24H28O2

Molecular Weight

348.5

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

AGN-191183, Arotinoid acid, Arotinoic acid, Ro 13-7410; 4-[(E)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]benzoic acid

TTNPB is a retinoic acid analog that selectively and potently activates the retinoic acid receptors. It is reported to increase the efficiency of induced pluripotent stem cell (iPSC) chemical reprogramming.

Appearance

Crystalline solid

Purity

≥98%

Solubility

Soluble to 10 mM in DMSO

Storage

Desiccate at -20°C

Purity

≥98%

Form

Crystalline solid

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References

Pignatello, M. A., Kauffman, F. C., & Levin, A. A. (1997). Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicology and applied pharmacology, 142(2), 319-327.|Åström, A., Pettersson, U., Krust, A., Chambon, P., & Voorhees, J. J. (1990). Retinoic acid and synthetic analogs differentially activate retinoic acid receptor dependent transcription. Biochemical and biophysical research communications, 173(1), 339-345.|Hossain, M. Z., & Bertram, J. S. (1994). Retinoids suppress proliferation, induce cell spreading, and up-regulate connexin43 expression only in postconfluent 10T1/2 cells: implications for the role of gap junctional communication. Cell growth & differentiation: the molecular biology journal of the American Association for Cancer Research, 5(11), 1253-1261.

USBio References

No references available

Technical Data