L-α-Aspartyl-3-mercapto-L-valyl-L-phenylalanyl-D-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-L-valine Cyclic (2→7)-Disulfide

Urantide acts as a competitice urotensin-II(UT) antagonist, blocking contractions in the thoracic aorta. Selective and competitive urotensin-II (UT) receptor antagonist pK = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).