Technical Data

257341
CAS Number
119478-56-7
Grade
Highly Purified
MDL Number
MFCD08600005
Molecular Formula
C₁₇H₃₁N₃O₈S
Molecular Weight
437.51
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Meropenem Trihydrate
[4R-[3(3S*,5S*),4α,5β,6β(R*)]]-3-[[5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate; (4R,5S,6S)-3-[[(3S,5S)-5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate; (4R,5S,6S)-3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate

A broad spectrum antibiotic that has a high affinity for cell wall-synthesizing enzymes.  It is a beta-lactam and belongs to the subgroup of carbapenem. The spectrum of action includes many gram-positive and gram-negative bacteria (including Pseudomonas) and anaerobic bacteria. Konagaya et al. note the successful elimination of Agrobacterium from Cryptomeria japonica (Japanese cedar) cultures using a concentration of 10mg/L of Meropenem without observing phytotoxic effects.

Synonyms
[4R-[3(3S*,5S*),4α,5β,6β(R*)]]-3-[[5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate; (4R,5S,6S)-3-[[(3S,5S)-5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate; (4R,5S,6S)-3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate
CAS No
119478-56-7
Molecular Formula
C₁₇H₃₁N₃O₈S
Molecular Weight
437.51
Purity (HPLC)
≥95%
Appearance
Off-white to yellowish powder
Specific Optical Rotation [α]20 (on dry basis)
-16.5 to -21.5°
Identity (1H NMR)
Conforms to structure
Water (KF)
11-13.5%
Storage and Stability
Store at -20ºC. Stable for 12 months after receipt.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Abe R, et al., Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation. J Immuno. 1995;154:985-97. (Immunogen, FC, IP, Costim). 2 .Dodson LF, et al. Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulation. Mol Cell Biol. 2009;29:3710-21. 3. Kanzaki M, et al. Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes. Endocrinology. 2012;153:612-20. (Costim). 4.Tomimori Y, et al., Repeated topical challenge with chemical antigen elicits sustained dermatitis in NC/Nga mice in specific- pathogen-free condition. J Invest Dermatol. 2005;124:119-24. (Costim). 5. Zhang T, et al. Selective CD28 blockade attenuates acute and chronic rejection of murine cardiac allografts in a CTLA-4-dependent manner. Am J Transplant. 2011;11:1599-1609. (Stim). 6.Jacobsen J, et al., Naive idiotope-specific B and T cells collaborate efficiently in the absence of dendritic cells. J Immunol. 2014;192:4174-83. (FC).
USBio References
No references available
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