Anhydrotetracycline Hydrochloride
(4S,4aS,12aS)-4-(Dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide hydrochloride; Tetracycline EP Impurity C Hydrochloride
Anhydrotetracycline hydrochloride is a synthetic tetracycline antibiotic that has been shown to be active against methicillin-resistant strains of Staphylococcus aureus and Enterobacteriaceae. It is also effective against Gram-positive bacteria such as Streptococcus pneumoniae, Enterococcus faecalis, and Listeria monocytogenes. Anhydrotetracycline hydrochloride functions by inhibiting protein synthesis, which prevents the production of proteins vital for cell division. This antibiotic inhibits translation by interfering with the binding of aminoacyl-tRNA to ribosomes through an unknown mechanism. Anhydrotetracycline hydrochloride has also been shown to enhance bacterial growth in the presence of carbon sources such as butanol or sugar alcohols.
Synonyms
(4S,4aS,12aS)-4-(Dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide hydrochloride; Tetracycline EP Impurity C Hydrochloride
CAS No
13803-65-1 Free Base: 1665-56-1
Molecular Formula
C₂₂H₂₃ClN₂O₇•HCl
Melting Point
203-205°C (dec.) (lit)
Solubility
DMSO: 10mg/ml DMF: 10mg/ml Ethanol: 2mg/ml
Storage and Stability
Lyophilized and reconstituted products are stable for 6 months after receipt at RT. Reconstitute with organic solvent. Aliquot to avoid repeated freezing and thawing. Store at RT. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
