Technical Data

262980
CAS Number
147536-97-8
Grade
Highly Purified
MDL Number
MFCD00867375
Molecular Formula
C27H29N5O6S
Molecular Weight
551.61
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
Bosentan
4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide; p-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)|-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide; Actelion; Ro 47-0203; Ro 47-0203/039; Tracleer

A mixed endothelin receptor antagonist. Used as a vasodilator. Antihypertensive.

Synonyms; 4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide; p-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy) -2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide; Actelion; Ro 47-0203; Ro 47-0203/039; Tracleer
CAS No
147536-97-8 157212-55-0 (hydrate)
Molecular Formula
C27H29N5O6S
Molecular Weight
551.62
Purity
≥98% (TLC)
Appearance
White to off-white solid
Identity (LCMS)
Conforms to structure
Melting Point
107-110°C (lit)
Solubility
DMSO (≥100mg/ml) (181.29mM)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Product is stable for 6 months from time of receipt.
Important Note
Toxicity and Hazards

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270:228 (1994); 2. Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10:717 (1996); 3. Weber, C., et al.: Clin Pharmacol. Ther., 60:124 (1996); 4. Krum, H., et al.: N. Engl. J. Med., 338:784 (1998)
USBio References
No references available
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