267778
CAS Number
179463-17-3Grade
Highly PurifiedMolecular Formula
C₅₆H₉₆N₁₀O₁₉Molecular Weight
1213.42EU Commodity Code
38220090Shipping Temp
RTStorage Temp
4°CCaspofungin Acetate
1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-(threo-3-hydroxy-L-ornithine)pneumocandin B0 Diacetate; Cancidas; Caspofungin Diacetate; L 743872; L 743873; MK 0991; 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]pneumocandin B0 Diacetate
An echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.
Synonyms
1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-(threo-3-hydroxy-L-ornithine)pneumocandin B0 Diacetate; Cancidas; Caspofungin Diacetate; L 743872; L 743873; MK 0991; 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]pneumocandin B0 Diacetate
Molecular Formula
C₅₆H₉₆N₁₀O₁₉
Appearance
White to off-white powder
Solubility
DMF: 20mg/ml; DMSO: 25mg/ml; Ethanol: 20mg/ml; PBS (pH 7.2): 3mg/ml
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C for 6 months from time of receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Sandhu, P. et al.: Antimicrob. Agents Chemorther., 48, 1272 (2004); Bertsche, T. et al.: Pharamaz. Zeit., 148, 34 (2003); Hoang, A.: Am. J. Health-Sys. Pharm., 58, 1206 (2001)USBio References
No references available