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268532 Chloroquine Diphosphate Salt CAS: 50-63-5

Specifications
References
CAS Number
50-63-5
Grade
Highly Purified
MDL Number
MFCD00069852
Molecular Formula
C₁₈H₃₂ClN₃O₈P₂
Molecular Weight
515.86
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine Diphosphate Salt; Aralen Diphosphate; Aralen Phosphate; Arechin; Avloclor; Bemaphate; Chingamin; Chingamin Phosphate; SN 7618; Sanoquin; Tanakan

Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine

Synonyms
N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine Diphosphate Salt; Aralen Diphosphate; Aralen Phosphate; Arechin; Avloclor; Bemaphate; Chingamin; Chingamin Phosphate; SN 7618; Sanoquin; Tanakan
CAS Number
50-63-5 Free Base: 54-05-7
Molecular Formula
C₁₈H₃₂ClN₃O₈P₂
Molecular Weight
515.86
Appearance
White to off-white crystalline powder
Purity
≥98.5%
Melting Point
195-199ºC
Loss on Drying
≤2%
Solubility
Water (Slightly, Heated)
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983)|2. Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998)|3. Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999)|4. Jiang et al (2010) Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. Biomed.Pharmacother. 64 609 PMID: 20888174|5. Sasaki et al (2010) Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer 10 370 PMID: 20630104
USBio References
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