Technical Data

276832
CAS Number
132684-60-7
Grade
Highly Purified
MDL Number
MFCD00065649
Molecular Formula
C21H23NO4
Molecular Weight
353.41
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
Fmoc-L-tert-Leucine
Fmoc-L-Tle-OH; Fmoc-L-alpha-t-butylglycine; Fmoc-α-t-butylglycine, N-α-Fmoc-L-α-t.-butyl-glycine; NPC 15573; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylbutanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-L-valine

Fmoc-L-tert-Leucine is an amide that is used for the treatment of prostate cancer. Fmoc-L-tert-Leucine has been shown to be effective in treating resistant prostate cancer cells in vivo, and it has been shown to inhibit the growth of prostate cancer cells in vitro. This drug also has a diagnostic effect on prostate cancer cells. The uptake of this drug by prostate cancer cells is dependent on the presence of caspase-9, which may be due to its ability to inhibit apoptosis.

Synonyms
Fmoc-L-Tle-OH; Fmoc-L-alpha-t-butylglycine; Fmoc-α-t-butylglycine, N-α-Fmoc-L-α-t.-butyl-glycine; NPC 15573; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylbutanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-L-valine
CAS No
132684-60-7
Molecular Formula
C21H23NO4
Molecular Weight
353.41
Purity
≥97% (HPLC)
Appearance
White to off-white solid
Melting Point
124-127°C (lit)
1H NMR Spectrum
Conforms to structure
Water (KF)
As Reported
Optical Rotation (c=1, Methanol)
As Reported
Storage and Stability
Powder may be stored at 4°C. Stable for 6 months after receipt
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Mizutani, H., et al.: J. Am. Chem. Soc., 124, 779 (2002). 2. Oost, T., et al.: J. Med. Chem., 47, 4417 (2004)
USBio References
No references available
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