276832
CAS Number
132684-60-7Grade
Highly PurifiedMDL Number
MFCD00065649Molecular Formula
C21H23NO4Molecular Weight
353.41EU Commodity Code
38220090Shipping Temp
RTStorage Temp
4°CFmoc-L-tert-Leucine
Fmoc-L-Tle-OH; Fmoc-L-alpha-t-butylglycine; Fmoc-α-t-butylglycine, N-α-Fmoc-L-α-t.-butyl-glycine; NPC 15573; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylbutanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-L-valine
Fmoc-L-tert-Leucine is an amide that is used for the treatment of prostate cancer. Fmoc-L-tert-Leucine has been shown to be effective in treating resistant prostate cancer cells in vivo, and it has been shown to inhibit the growth of prostate cancer cells in vitro. This drug also has a diagnostic effect on prostate cancer cells. The uptake of this drug by prostate cancer cells is dependent on the presence of caspase-9, which may be due to its ability to inhibit apoptosis.
Synonyms
Fmoc-L-Tle-OH; Fmoc-L-alpha-t-butylglycine; Fmoc-α-t-butylglycine, N-α-Fmoc-L-α-t.-butyl-glycine; NPC 15573; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylbutanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-L-valine
Molecular Formula
C21H23NO4
Appearance
White to off-white solid
Melting Point
124-127°C (lit)
1H NMR Spectrum
Conforms to structure
Optical Rotation (c=1, Methanol)
As Reported
Storage and Stability
Powder may be stored at 4°C. Stable for 6 months after receipt
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Mizutani, H., et al.: J. Am. Chem. Soc., 124, 779 (2002). 2. Oost, T., et al.: J. Med. Chem., 47, 4417 (2004)USBio References
No references available