Fmoc-O-tert-butyl-L-trans-4-hydroxyproline (Fmoc-L-Hyp(tBu)-OH)
Fmoc-L-Hyp(tBu)-OH; (2S-trans)-4-(1,1-Dimethylethoxy)-1,2-Pyrrolidinedicarboxylic Acid 1-(9H-fluoren-9-ylmethyl) Ester
Fmoc-O-tert-butyl-L-trans-4-hydroxyproline is a synthetic, cleavable peptide that can be used as a biomaterial. It is synthesized by coupling Fmoc-O-(tert-butoxycarbonyl)-L-trans(4R)-hydroxyproline with the amino acid N,N'-diisopropylcarbodiimide and 4-(dimethylamino)pyridine in a microwave reactor. The peptide has been shown to inhibit the enzyme matrix metalloproteinase 9 (MMP9), which plays an important role in tumor cell invasion and metastasis. This compound also has the ability to form conjugates with other molecules, such as lipopeptides, which may improve its therapeutic potential.
Synonyms
Fmoc-L-Hyp(tBu)-OH; (2S-trans)-4-(1,1-Dimethylethoxy)-1,2-Pyrrolidinedicarboxylic Acid 1-(9H-fluoren-9-ylmethyl) Ester
Molecular Formula
C₂₄H₂₇NO₅
Appearance
White to off-white powder
1H-NMR Spectrum
Conforms to reference
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. Stable for 6 months after receipt.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
