278374
CAS Number
317318-70-0Grade
Highly PurifiedMolecular Formula
C₂₁H₁₈F₃NO₃S₂Molecular Weight
453.5EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°CGW 501516
2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid; Methyl-methyl-trifluoromethylphenyl|-thiazolyl-methylsulfanyl-phenoxy-acetic Acid; GW 1516; Endurobol
An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.
Synonyms
2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid; Methyl-methyl-trifluoromethylphenyl -thiazolyl-methylsulfanyl-phenoxy-acetic Acid; GW 1516; Endurobol
Molecular Formula
C₂₁H₁₈F₃NO₃S₂
Appearance
White to yellow powder
Solubility
DMSO (Slightly), Methanol (Slightly)
Storage and Stability
May be stored at 4°C for short-term. For long-term storage, aliquot and store at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001), Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2003), Wang, Y.X., et al.: Cell, 113, 159 (2003),USBio References
No references available