Technical Data

278817
CAS Number
19685-09-7
Grade
Highly Purified
MDL Number
MFCD02093100
Molecular Formula
C₂₀H₁₆N₂O₅
Molecular Weight
364.35
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
10-Hydroxycamptothecin
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-Hydroxycamptothecin; Hydroxycamptothecin; NSC 107124

10-Hydroxycamptothecin is a cytotoxic drug that inhibits the polymerase chain reaction. It has been shown to have inhibitory properties against cancer cells in vitro and in vivo. 10-Hydroxycamptothecin binds to DNA and prevents the synthesis of RNA or proteins. This drug is also able to induce apoptosis in certain cancer cell lines, including breast and colon cancers. The mechanism of action of 10-hydroxycamptothecin is not fully understood, but it may involve an intermolecular hydrogen bonding between the drug and the DNA, which inhibits transcription and replication. 10-Hydroxycamptothecin is used for the treatment of various types of cancers such as non-small cell lung cancer, small cell lung cancer, colorectal cancer, gastric cancer, pancreatic cancer, prostate cancer, breast cancer, ovarian cancer, esophageal carcinoma, head and neck squamous cell carcinoma (HNSCC),

Synonyms
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-Hydroxycamptothecin; Hydroxycamptothecin; NSC 107124
CAS Number
19685-09-7
Molecular Formula
C₂₀H₁₆N₂O₅
Molecular Weight
364.35
Solubility
DMSO: 50 mg/mL (ultrasonic)
Purity
≥99.38%
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Wani, M.C., et al.: J. Med. Chem., 29, 2358 (1986), Miller, K.D., et al.: Invest. New Drugs, 22, 69 (2004), Punt, C.J.A., et al.: Eur. J. Cancer, 40, 1332 (2004), Wang, J.-Q., et al.: Bioorg. Med. Chem., 13, 549 (2005)
USBio References
No references available
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