(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-Hydroxycamptothecin; Hydroxycamptothecin; NSC 107124

10-Hydroxycamptothecin is a cytotoxic drug that inhibits the polymerase chain reaction. It has been shown to have inhibitory properties against cancer cells in vitro and in vivo. 10-Hydroxycamptothecin binds to DNA and prevents the synthesis of RNA or proteins. This drug is also able to induce apoptosis in certain cancer cell lines, including breast and colon cancers. The mechanism of action of 10-hydroxycamptothecin is not fully understood, but it may involve an intermolecular hydrogen bonding between the drug and the DNA, which inhibits transcription and replication. 10-Hydroxycamptothecin is used for the treatment of various types of cancers such as non-small cell lung cancer, small cell lung cancer, colorectal cancer, gastric cancer, pancreatic cancer, prostate cancer, breast cancer, ovarian cancer, esophageal carcinoma, head and neck squamous cell carcinoma (HNSCC),