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279171 6a-Hydroxy Paclitaxel CAS: 153212-75-0

Specifications
References
CAS Number
153212-75-0
Grade
Highly Purified
Molecular Formula
C₄₇H₅₁NO₁₅
Molecular Weight
869.91
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
6α-hydroxy Taxol; βS-(benzoylamino)-αR-hydroxy-(2aR,3S,4R,4aS,6R,9S,11S,12S,12aR,12bS,)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-3,4,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester-benzenepropanoic acid

6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel (Item No. 10461), produced by the action of the cytochrome P450 isoform CYP2C8.1,2 The generation of 6α-hydroxy paclitaxel by CYP2C8 can be impacted by other drugs (e.g., fluvastatin, Item No. 10010334) or dietary components that interefere with CYP2C8 activity, as well as by CYP2C8 genetic polymorphisms.3,4,5

Synonyms
βS-(benzoylamino)-αR-hydroxy-(2aR,3S,4R,4aS,6R,9S,11S,12S,12aR,12bS,)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-3,4,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester-benzenepropanoic acid
CAS Number
153212-75-0
Molecular Formula
C₄₇H₅₁NO₁₅
Molecular Weight
869.91
Appearance
Crystalline solid
Purity
≥95%
Solubility
Soluble in DMSO at 30mg/ml, in water at 1mg/ml and Methanol at 10mg/ml.
Storage and Stability
May be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with solvent. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards:  All products should be handled by qualified personnel only, trained in laboratory procedures.
Purity
≥95%
Form
Crystalline solid
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Kumar, G.N., Oatis, J.E., Jr., Thornburg, K.R., et al. 6 alpha-Hydroxytaxol: Isolation and identification of the major metabolite of taxol in human liver microsomes. Drug Metabolism and Disposition 22:177-179 (1994). 2. Walle, T., Kumar, G.N., McMillian, J.M., et al. Taxol metabolism in rat hepatocytes. Biochemical Pharmacology 46(9):1661-1664 (1993). 3. Fischer, V., Johanson, L., Heitz, F., et al. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: Effect on human cytochrome P-450 and implications for metabolic drug interactions. Drug Metabolism and Disposition 27(3):410-416 (1999). 4. Quintieri, L., Palatini, P., Moro, S., et al. Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin. Drug Metab.Pharmacokinet. 26(6):559-568 (2011). 5. Saito, Y., Katori, N., Soyama, A., et al. CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population. Pharmacogenetics and Genomics 17(7):461-471 (2007).
USBio References
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