280658
CAS Number
51-30-9Grade
Highly PurifiedMDL Number
MFCD00012603Molecular Formula
C₁₁H₁₈ClNO₃Molecular Weight
247.72EU Commodity Code
38220090Shipping Temp
RTStorage Temp
4°CIsoproterenol Hydrochloride
4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol Hydrochloride; Isovon; Isuprel; Mistarel; NSC 37745; NSC 89747; Proternol; Saventrine; Suscardia; Vapo-Iso; dl-Isadrine Hydrochloride; dl-Isoprenaline Hydrochloride; dl-Isopropylnoradrenaline Hydrochloride; dl-Isopropylnorepinephrine Hydrochloride; α-(Isopropylaminomethyl)-3,4-dihydroxybenzyl alcohol Hydrochloride; 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol Hydrochloride
Isoproterenol is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator. Activation of β2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation.
Solubility
DMSO (Slightly), Methanol (Slightly), Water (Slightly) Soluble to 100mM in water Phosphate buffered saline to 50mM
Method for Determining Identity
Proton NMR (D2O) spectroscopic analysis and mass spectrometric analysis
TLC Conditions
SiO2; Dichloromethane : Methanol : Ammonium Hydroxide (4 : 1 : 0.1). Visualized with UV and AMCS (single spot; Rf=0.35).
Storage and Stability
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Kikkawa, H. et al.: Biol. Pharmac. Bull., 17, 1047 (1994)|2. Kral, P. et al.: Psychopharmacologia, 26, 79 (1972)|3. Giles, R.E. et al.: J. Pharmacol. Exp. Ther., 186, 472 (1973)|4. Akimoto et al (2002) Nitric oxide (NO) primarily accounts for endothelium-dependent component of β-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline. J.Smooth Muscle Res. 38 87. PMID: 12596888.|5. Schmitt and Stork (2000) β2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf. J.Biol.Chem. 275 25342. PMID: 10840035.|6. Lotti et al (1982) Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: selective supersensitivity to beta 2-mediated responses following reserpine treatment. J.Auton.Pharmacol. 2 169. PMID: 6292228.USBio References
No references available