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281048 (+)-JQ-1 CAS: 1268524-70-4

Specifications
References
CAS Number
1268524-70-4
Grade
Highly Purified
Molecular Formula
C₂₃H₂₅ClN₄O₂S
Molecular Weight
456.99
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic Acid 1,1-Dimethylethyl Ester; (+)-JQ1; (S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.

Synonyms
(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic Acid 1,1-Dimethylethyl Ester; (+)-JQ1; (S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
CAS Number
1268524-70-4
Molecular Formula
C₂₃H₂₅ClN₄O₂S
Molecular Weight
456.99
Appearance
White to yellow crystalline powder
Purity
≥98%
References
Li, Z.C., et al.: Nuc. Acids. Res., 41, 277 (2013); Hay, D., et al.: Med. Chem. Comm., 4, 140 (2013)
USBio References
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