Technical Data

281105
CAS Number
65277-42-1
Grade
Highly Purified
MDL Number
MFCD00865612
Molecular Formula
C26H28Cl2N4O4
Molecular Weight
531.43
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
Ketoconazole
rel-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone; cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; (+/-)-Ketoconazole

Ketoconazole is an inhibitor of cytochrome P450c17. Enhances the formation of myelin basic protein-positive oligodendrocytes from oligodendrocyte progenitor cells in vitro and promotes remyelination in vivo. Also an antifungal agent. Brain penetrant. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. Inhibitor of exosome secretion.

Synonyms
rel-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone; cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; (+/-)-Ketoconazole
CAS No
65277-42-1
Molecular Formula
C26H28Cl2N4O4
Molecular Weight
531.43
Purity
≥98%
Appearance
White to light brown powder
Melting Point
148-152ºC
Loss on Drying (80°C, 4hr)
≤0.5%
Solubility
Ethanol, DMSO, Chloroform (Slightly), Methanol (Slightly)
Storage and Stability
Store at 4ºC. Stable for 6 months after receipt.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Lambert, A., et al., Biochem. Pharmacol., 35, 3999 (1986). 2. Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989). 3. Nardone, P.A., et al., . Surg. Res., 44, 425 (1988). 4. Tucker, W.F.G., et al., Br. Med. J., 293, 882 (1986)
USBio References
No references available
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