285114
CAS Number
159989-65-8Grade
Highly PurifiedMDL Number
MFCD00931436Molecular Formula
C₃₃H₄₉N₃O₇S₂Molecular Weight
663.89EU Commodity Code
38220090Shipping Temp
RTStorage Temp
-20°CNelfinavir Mesylate
AG-1343, AG1343, Viracept; (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-ph|enylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide;methanesulfonic acid
Nelfinavir is a potent competitive inhibitor of the HIV-1 protease. It is reported that it can also inhibit the growth of various cell types and trigger apoptosis. Besides being a protease inhibitor used in the therapeutic agent for acquired immunodeficiency syndrome (AIDS), it is also stimulates autophagy and and exhibits anti-cancer properties. It appears to do by inhibition of the Akt/PKB signaling pathway and activation of endoplasmic reticulum stress with subsequent unfolded protein response (1). Nelfinavir has also been shown to treat SARS-coronavirus (2), and is being tested currently to treat COVID-19.
Synonyms
AG-1343, AG1343, Viracept; (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-ph enylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide;methanesulfonic acid
Molecular Formula
C₃₃H₄₉N₃O₇S₂
Solubility
DMSO (100mM), Methanol (Slightly)
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Patick, A.K., et al.: Antimicrob. Agents Chemother., 40, 292 (1996), Bardsley-Elliot, G.L., et al.: Drugs, 59, 581 (2000USBio References
No references available