286712
CAS Number
100-33-4Grade
Highly PurifiedMDL Number
MFCD00599574Molecular Formula
C19H24N4O2Molecular Weight
340.42EU Commodity Code
38220090Shipping Temp
RTStorage Temp
-20°CPentamidine
4,4'-[1,5-Pentanediylbis(oxy)]bis-benzenecarboximidamide; 4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane; MP 601205; NSC 9921
Pentamidine is an aromatic diamine that is effective against protozoal diseases, such as amoebic dysentery, malaria, trypanosomiasis, and leishmaniasis. In clinical studies, it has also been shown to be an effective prophylaxis against pneumocystis pneumonia.
Synonyms
4,4'-[1,5-Pentanediylbis(oxy)]bis-benzenecarboximidamide; 4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane; MP 601205; NSC 9921
Molecular Formula
C19H24N4O2
Purity
≥98% (HPLC and TLC)
Appearance
Crystalline solid
Solubility
DMF: 25mg/ml; DMF: PBS (pH 7.2) (1:2): 0.33mg/ml; DMSO: 20mg/ml; Ethanol: 10mg/ml
Storage and Stability
Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Goa, K.L., et al., Drugs, 33, 242 (1987). 2. Debs, R.J., et al., Antimicrob. Agents Chemother., 31, 37 (1987). 3. Walzer, P.D., et al., Antimicrob. Agents Chemother., 32, 896 (1988). 4. Hesk, D., et al., J. Lab. Comp. Radiopharm., 28, 11, 1309 (1990)USBio References
No references available