Technical Data

289075
CAS Number
1069-66-5
Grade
Highly Purified
MDL Number
MFCD00078604
Molecular Formula
C8H15NaO2
Molecular Weight
166.19
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
Sodium Valproate
HDAC Inhibitor; 2-Propylpentanoic Acid Na; Depacon; Depakin; Depakine; Epilim; Ergenyl; Leptilan; Orfiril

Histone deacetylase inhibitor (IC50=400uM). Demonstrates neuroprotective, anticancer and anti-inflammatory activity. Inhibits ABeta production and neuritic plaque formation in Alzheimer’s mouse models. Clinically useful anticonvulsant.

Synonyms
Sodium Valproate, HDAC Inhibitor; 2-Propylpentanoic Acid Na; Depacon; Depakin; Depakine; Epilim; Ergenyl; Leptilan; Orfiril
CAS No
1069-66-5 Free acid: 99-66-1
Molecular Formula
C8H15NaO2
Molecular Weight
166.19
Purity
≥98.5%
Appearance
White to off-white solid
Identity (IR)
Conforms to structure
Melting Point
>300ºC (lit.)
Loss on Drying
≤2%
Identity (Reactions of sodium salt)
Conforms
Heavy Metals
≤0.002%
Acidity or Alkalinity
max 0.75ml of either 0.1M NaOH or 0.1M HCl
Chloride
≤0.02%
Clarity and Color
Conforms to EP6
Related Substances (GC)
≤0.1%
Sulfate
≤0.02%
Total Impurities (GC)
≤0.3%
Solubility
Ethanol (Slightly), Methanol (Slightly), Water (Slightly)
Storage and Stability
Store at RT. Hygroscopic.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8:529 (1979), 2. Nau, H., et al.: Pharmacol. Toxicol., 69:310 (1991), 3. Loscher, W., et al.: Prog. Neurobiol., 58:31 (1999)
USBio References
No references available
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