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289075 Sodium Valproate CAS: 1069-66-5

Specifications
References
CAS Number
1069-66-5
Grade
Highly Purified
MDL Number
MFCD00078604
Molecular Formula
C8H15NaO2
Molecular Weight
166.19
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
HDAC Inhibitor; 2-Propylpentanoic Acid Na; Depacon; Depakin; Depakine; Epilim; Ergenyl; Leptilan; Orfiril

Histone deacetylase inhibitor (IC50=400uM). Demonstrates neuroprotective, anticancer and anti-inflammatory activity. Inhibits ABeta production and neuritic plaque formation in Alzheimer’s mouse models. Clinically useful anticonvulsant.

Synonyms
Sodium Valproate, HDAC Inhibitor; 2-Propylpentanoic Acid Na; Depacon; Depakin; Depakine; Epilim; Ergenyl; Leptilan; Orfiril
CAS No
1069-66-5 Free acid: 99-66-1
Molecular Formula
C8H15NaO2
Molecular Weight
166.19
Purity
≥98.5%
Appearance
White to off-white solid
Identity (IR)
Conforms to structure
Melting Point
>300ºC (lit.)
Loss on Drying
≤2%
Identity (Reactions of sodium salt)
Conforms
Heavy Metals
≤0.002%
Acidity or Alkalinity
max 0.75ml of either 0.1M NaOH or 0.1M HCl
Chloride
≤0.02%
Clarity and Color
Conforms to EP6
Related Substances (GC)
≤0.1%
Sulfate
≤0.02%
Total Impurities (GC)
≤0.3%
Solubility
Ethanol (Slightly), Methanol (Slightly), Water (Slightly)
Storage and Stability
Store at RT. Hygroscopic.
References
1. Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8:529 (1979), 2. Nau, H., et al.: Pharmacol. Toxicol., 69:310 (1991), 3. Loscher, W., et al.: Prog. Neurobiol., 58:31 (1999)
USBio References
No references available
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