Technical Data

295150
CAS Number
30516-87-1
Grade
Highly Purified
Molecular Formula
C₁₀H₁₀D₃N₅O₄
Molecular Weight
270.26
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
3'-Azido-3'-deoxythymidine methyl-D3
AZT-d3; Zidovudine-d3; Retrovis-d3; Timazid-d3; Retrovir-d3; NSC 602670-d3

A deuterated, potent and selective inhibitor of HIV-1 replication.

Synonyms
AZT-d3; Zidovudine-d3; Retrovis-d3; Timazid-d3; Retrovir-d3; NSC 602670-d3
CAS No
30516-87-1
Molecular Formula
C₁₀H₁₀D₃N₅O₄
Molecular Weight
270.26
Purity (HPLC)
≥99%
Isotopic Purity
≥97%
Appearance
White to off-white solid
Solubility
DMSO (Slightly), Methanol (Slightly)
Proton NMR (DMSO-d6) and MS
Conforms to reference
TLC Conditions
SiO2; Dichloromethane : Methanol = 9 : 1; Visualized with UV and AMCS; Single Spot, Rf = 0.50.
Elemental Analysis
Calculated: %C: 44.44, %H: 4.85, %N: 25.91
Normalized Intensity
d0 = 0.46%, d1 = 0.76%, d2 = 4.61%, d3 = 94.17%
Specific Rotation
+62.5° (c=0.2, Ethanol)
Melting Point
118-120°C
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Mitsuya, H., et al.: Nature, 325, 773 (1987). 2. Brehm, J., et al.: Biochem., 47, 14020 (2008). 3. Paredes, R., et al.: J. Virol., 83, 2038 (2009). 4. Wan, J., et al.: J. Med. Chem., 52, 1144 (2009). 5. Mainardes, R., et al.: J. Pharm. Sci., 98, 257 (2009)
USBio References
No references available
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