3'-Azido-3'-deoxythymidine methyl-D3 CAS 30516-87-1

CAS Number

30516-87-1

Grade

Highly Purified

Molecular Formula

C₁₀H₁₀D₃N₅O₄

Molecular Weight

270.26

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C

AZT-d3; Zidovudine-d3; Retrovis-d3; Timazid-d3; Retrovir-d3; NSC 602670-d3

A deuterated, potent and selective inhibitor of HIV-1 replication.

Synonyms

AZT-d3; Zidovudine-d3; Retrovis-d3; Timazid-d3; Retrovir-d3; NSC 602670-d3

CAS No

30516-87-1

Molecular Formula

C₁₀H₁₀D₃N₅O₄

Molecular Weight

270.26

Purity (HPLC)

≥99%

Isotopic Purity

≥97%

Appearance

White to off-white solid

Solubility

DMSO (Slightly), Methanol (Slightly)

Proton NMR (DMSO-d6) and MS

Conforms to reference

TLC Conditions

SiO2; Dichloromethane : Methanol = 9 : 1; Visualized with UV and AMCS; Single Spot, Rf = 0.50.

Elemental Analysis

Calculated: %C: 44.44, %H: 4.85, %N: 25.91

Normalized Intensity

d0 = 0.46%, d1 = 0.76%, d2 = 4.61%, d3 = 94.17%

Specific Rotation

+62.5° (c=0.2, Ethanol)

Melting Point

118-120°C

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

References

1. Mitsuya, H., et al.: Nature, 325, 773 (1987). 2. Brehm, J., et al.: Biochem., 47, 14020 (2008). 3. Paredes, R., et al.: J. Virol., 83, 2038 (2009). 4. Wan, J., et al.: J. Med. Chem., 52, 1144 (2009). 5. Mainardes, R., et al.: J. Pharm. Sci., 98, 257 (2009)

USBio References

No references available

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295150 3'-Azido-3'-deoxythymidine methyl-D3 CAS: 30516-87-1

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

AZT-d3; Zidovudine-d3; Retrovis-d3; Timazid-d3; Retrovir-d3; NSC 602670-d3

References

USBio References

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