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295546 N6-Benzyladenosine 5'-O-triphosphate sodium salt, 10mM aqueous solution CAS: 40922-97-2

Specifications
References
CAS Number
40922-97-2
Grade
Highly Purified
Molecular Formula
C17H22N5O13P3
Molecular Weight
597.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Agonistic ligand, mainly for nucleoside receptor A1, with less affinity to A2A and A3 Nucleoside-triphosphates can be converted by different membrane- bound phosphatases into nucleosides acting as nucleoside receptor ligands. In some cases nucleoside phosphates act also directly on nucleoside receptors.

CAS Number
40922-97-2 (free acid)
Molecular Formula
C17H22N5O13P3
Molecular Weight
97.30
Appearance
10mM aqueous solution
Purity
≥95%
Storage
-20°C
References
Sirci et al. (2012) Ligand-, structure- and pharmacophore-based molecular fingerprints: a case study on adenosine A1, A2A, A2B, and A3 receptor antagonists. J. Comput. Aided Mol. Des. 26:1247.|Volonte et al. (2009) Membrane components and purinergic signalling: the purinome, a complex interplay among ligands, degrading enzymes, receptors and transporters. FEBS J. 276:318.|Yegutkin (2008) Nucleotide and nucleoside converting enzymes: Important modulators of purinergic signalling cascade. Biochim. Biophys. Acta 1783:673.|Joshi et al. (2005) Purine derivatives as ligands for A3 adenosine receptors. Current Topics in Medicinal Chemistry 5:1275.|Zhou et al. (2005) High affinity ATP/ADP analogues as new tools for studying CFTR gating. J. Physiol. 569 (2):447.|Hess (2001) Recent advantages in adenosine receptor antagonist research. Expert Opin. Ther. Patents 11 (10):1533.|Jacobson (2001) Probing adenosine and P2 receptors: design of novel purines and nonpurines as selective ligands. Drug Development Res. 52:178.|Jacobson et al. (2001) Ribose modified nucleosides and nucleotides as ligands for purine receptors. Nucleosides, Nucleotides & Nucleic Acids 20 (4):333.|Gillespie et al. (1999) Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N (6)-modified ADP analogs. J. Biol. Chem. 274 (44):31373.|Van Galen et al. (1994) A binding site model and structure-activity relationships for rat A3 adenosine receptor. Molecular Pharmacology 45:1101.
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