SCR7 Pyrazine CAS 14892-97-8

CAS Number

14892-97-8

Grade

Highly Purified

Molecular Formula

C₁₈H₁₂N₄OS

Molecular Weight

332.38

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

4°C

2,3-Dihydro-6,7-diphenyl-2-thioxo-4 (1H)-pteridinone; 6,7-Diphenyl-2-thio-lumazine

SCR7 pyrazine also is a potent inhibitor of nonhomologous endjoining (NHEJ) mediated by DNA ligase IV. It enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro upt to 19-fold. SCR7 pyrazine is a product of spontaneous cyclization of CRISPR enhancer SCR7 first reported by Srivastava, M., et al.

DNA ligase IV seals double-strand breaks during the process of nonhomologous end-joining in DNA repair. Inhibiting this function in cancer cells is one strategy to prevent deleterious cell growth. SCR7 is a small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with ligase binding and activating apoptosis.1 It also inhibits ligase III, but does not affect the activity of T4 DNA ligase or ligase I. SCR7 has been used to increase the rate of homology directed repair triggered by DNA double-strand breaks and to inhibit cancer cell growth in vitro (IC50s = 8-120 µM) and in mouse models when co-administered with double-strand break-inducing therapeutic compounds.1,2,3,4

Synonyms

2,3-Dihydro-6,7-diphenyl-2-thioxo-4 (1H)-pteridinone; 6,7-Diphenyl-2-thio-lumazine

CAS No

14892-97-8

Molecular Formula

C₁₈H₁₂N₄OS

Molecular Weight

332.38

Appearance

Supplied as a yellow solid.

Purity

≥95%

Solubility

Soluble to 100mM in DMSO and to 20mM in ethanol

Storage and Stability

Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

1. Chu et al (2015) Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat.Biotechnol. 33: 543. PMID: 25803306. 2. Maruyama et al (2015) Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat.Biotechnol. 33: 538. PMID: 25798939.

USBio References

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351748 SCR7 Pyrazine CAS: 14892-97-8

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

2,3-Dihydro-6,7-diphenyl-2-thioxo-4 (1H)-pteridinone; 6,7-Diphenyl-2-thio-lumazine

References

USBio References

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