Technical Data

366879
CAS Number
866405-64-3
Grade
Highly Purified
MDL Number
MFCD08705402
Molecular Formula
C24H25N5
Molecular Weight
399.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Dorsomorphin
Compound C, AMPK Inhibitor, BML-275, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Synonyms
Compound C, AMPK Inhibitor, BML-275
Chemical Name
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Molecular Formula
C24 H25 N5
Molecular Weight
399.5
CAS Number
866405-64-3
Purity
≥98%
Applications
FA
Appearance: Crystalline solid
Description
Dorsomorphin is a potent and selective inhibitor of the BMP pathway through the ALK2, ALK3, and ALK6 receptors. It is also a selective and reversible inhibitor of the AMP-activated protein kinase (AMPK). Dorsomorphin is reported to be useful in promoting specific cell differentiation and inducing cancer cell line autophagy.
Storage
Soluble in organic solvents such as ethanol and DMF.
Purity
Highly Purified (~98%)
Concentration
Not determined
Form
Supplied as a crystalline solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Paul, B. Y., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., Peterson, R. T. (2008). Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature chemical biology, 4(1), 33-41. 2. Hao, J., Daleo, M. A., Murphy, C. K., Yu, P. B., Ho, J. N., Hu, J., Hong, C. C. (2008). Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PloS one, 3(8), e2904. 3. Boergermann, J. H., Kopf, J., Yu, P. B., Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry cell biology, 42(11), 1802-1807.
USBio References
No references available
United States Biological | 4 Technology Way | Salem, MA 01970
Phone 800-520-3011 | Fax 978-594-8052 | Website www.usbio.net